Bir tekstil fabrikasında çalışan astımlı işçilerin değerlendirilmesi

Objective: Workers with asthma are one of the risk working groups. Being exposed to indoor air pollutants in the workplace makes it difficult to control asthma and can lead to asthma attacks. This study was conducted by a workplace physician of a textile factory in Denizli, 2009, and it was investigated whether workers with asthma were affected or not in the workplace. Material and Method: Some data about health/diseases status and individual characteristics of 41 workers who had previously been diagnosed with asthma were collected. Spirometric measurements were made. PEF (peak expiratory flow) meters recordings were made 4 times a day during 4 weeks to indicate the effects of the workplace. PEF rates were calculated using the measurements before and after the shift. Results: There were 1553 workers in the factory and 41 of them had asthma (2.6%). Twenty-eight of them were female. Nearly half of the workers with asthma were smoking more than 5 cigarettes per day. PFT (pulmonary function test) measurements were lower in workers with asthma. PFT measurements were lower in current smoker workers with asthma than in nonsmoker. When we evaluated PEF measurements; we found 8% decrease between the start and end of the shifts. Nearly half of the PFT results of asthma workers were found to be normal. Daily PEFR variability of more than 20% was 4.4%. Conclusion: The 75.6% of asthmatic workers were current smokers. Also, all workers having a daily PEFR variability higher than 20% were current smokers. These findings indicate that smoking is the most important problem that must be solved. A smoking cessation programme has been initiated for workers

Investigation of the Pathogenesis and Treatment Efficiency of Bevacizumab-Induced Hypertension in the Rat Model

Bevacizumab is known to reduce Vascular Endothelial Growth Factor (VEGF) to undetectable levels when used in conjunction with chemotherapy. Hypertension is a frequent adverse effect of bevacizumab, although its mechanism(s) remain unclear. In this study, our aim was to examine the pathogenesis of bevacizumab-induced hypertension and to investigate the treatment efficacy of valsartan. A total of 24 Wistar Albino female rats were included in the study. Rats were divided into three groups with 8 rats in each, as follows: The control group, bevacizumab group and bevacizumab + valsartan group. Blood pressure, blood urea nitrogen and serum creatinine levels were measured, urine samples were collected for 24 hours statistical analyses were performed using IBM SPSS 20 software pack. Nephrectomy specimens in bevacizumab and bevacizumab + valsartan groups exhibited varying degrees of renal injury. Although valsartan was able to reduce the bevacizumab-induced rise in blood pressure, it could not prevent the development of nephropathy. Conclusions these findings suggest that hypertension occurring secondary to bevacizumab treatment in rats may be associated with mechanisms involving renal injury

MATHEMATICAL MODELLING OF PLACEMENT OF EMERGENCY PHONE CENTRES IN A CAMPUS NETWORK

Bir G grafında, seçilen bazı tepeler yardımıyla grafın tüm ayrıtlarını tanımlama graf örtüsü problemi olarak bilinir. Başka bir açıdan bakıldığında örtü problemi; sayılabilir bir küme üzerinde verilmiş bir bağıntıyı, bu kümenin minimum sayıda elemanını kullanarak tanımlama olarak düşünülebilir. Optimizasyon teorisinde; bir G grafının örtü kümeleri içinden en az elemanlısını bulmaya minimal örtü problemi adı verilir. Bu problem literatürde bir discrete optimizasyon problemi olarak bilinmektedir. Problem doğrusal programlama ile matematiksel olarak ifade edilebilir. Bu çalışmada iletişim ağı grafla modellenerek, bu ağda ilişkileri minimum sayıda elemanla tanımlayan graf örtüsü problemi ele alınmıştır. Örtü probleminin genel doğrusal programlama modeli verilerek çözüm araştırılmıştır. Daha sonra uygulama problemi olarak ele alınan, Ege Üniversitesi Kampüsünde güvenliği sağlamak amacıyla acil telefonlarının yerleştirilmesi problemi, bir örtü problemi olarak modellenmiştir. Elde edilen doğrusal programlama problemi WQSB programı yardımı ile çözülüp minimum sayıda hangi noktalara telefon yerleştirilmesi gerektiği hesaplanmıştır. In this study graph set covering problem which is a problem of defining relations in a network by using less number of objects, is examined by the aid of graphs that are used mostly in design of communication networks. Cover problem is also known as the distinct optimization problem in this field of study. The problem of placement of emergency phones in Ege University Campus to provide security is considered as a cover problem. The obtained linear programming problem is solved by WQSB and the result that at least number of places which a phone is required to be placed, is found

Evaluation of vertebral bone mineral density in scoliosis by using quantitative computed tomography

Purpose: Scoliosis is described as a lateral curvature of the spine. We aimed to evaluate bone mineral density (BMD) in patients with scoliosis by using quantitative computed tomography (QCT) and compare the BMD of idiopathic and congenital scoliosis patients. Material and methods: Forty-three patients aged 1 to 40 years with idiopathic, congenital, or neuromuscular scoliosis and 41 matched controls of the same sex and approximate age were included in the study. Measurements of BMD were performed by QCT analysis for each vertebral body from T12 to L5, and mean BMD was calculated for each case. Results: Twenty-two of the patients with scoliosis were idiopathic, 15 were congenital, four were neuromuscular, and two were neurofibromatosis. The mean BMD values of patients with scoliosis were significantly lower compared with the control group (106.8 ± 33.4 mg/cm3 vs. 124.9 ± 29.1 mg/cm3, p = 0.009). No significant difference in BMD values was found between idiopathic and congenital scoliosis patients (p > 0.05). Conclusions: This study illustrated that the vertebral body BMD values of the patients with scoliosis were significantly lower than those seen in the control group

Paget’s Disease Mimicking Bone Metastasis in a Patient with Neuroendocrine Tumor on 68Ga-DOTANOC PET/CT

Somatostatin (SST) is a neuropeptide present in neurons, endocrine cells, and a wide range of neuroendocrine tumors (NETs). 68Ga-DOTATOC, 68Ga-DOTANOC, and 68Ga-DOTATATE are current SST analogues used for PET/CT which bind to SST receptors expressed in NETs. These SST analogues have been used successfully for diagnosis of SST-expressing tumors with a more sensitive detection technique than conventional scintigraphy. However, there is a lack of clinical data on the differentiation between NETs and other malignant tumors or benign pathological conditions. Here, we report a case of Paget’s disease mimicking bone metastasis of NET on PET/CT due to increased 68Ga-DOTANOC uptake and review examples of similar cases in the literature

Organizational Socialization and Its Relation with Organizational Performance in High Schools

This study is designed to explore organizational socialization and organizational performance levels of secondary school teachers and the relation between the two variables mentioned. The study is designed as correlational research. The target population of the research consists of 5744 teachers who work in public and private Anatolian high schools in the center of Ankara, the capital city of Turkey. Using the stratified sampling technique, 650 participant teachers have been included in the sample. This study has revealed that the participants are relatively more socialized in the organizational socialization language factor, which is followed by socialization levels in the following factors: performance proficiency, people, history, organizational goals and values, and politics. The socialization levels of teachers indicate significant differences in the history and language factors according to gender. In all the factors, the participant private school teachers are found to be more socialized than the public school teachers. Their organizational performance levels significantly vary according to gender and type of school. The performance of teachers in private schools is relatively higher than that of those in public schools. There is a significant, moderate positive relation between organizational socialization and organizational performance

Development of an optimum proliferation medium via the graph kernel statistical analysis method for genetically stable in vitro propagation of endemic Thymus cilicicus (Turkey)

Thymus cilicicus is an endemic Eastern Mediterranean element that has aromatic-medicinal properties. Its natural population spreads across gravelly ground and open rocky areas of South and Southwest Anatolia. The current study on in vitro propagation of T. cilicicus focused deeply on environmental applications such as the development of an optimum medium composition for efficient and genetically stable micropropagation and improved preservation procedures for long-time conservation of elite germplasms for further studies. For this purpose, MS and OM media were used individually and in combination with cytokinins, charcoal, AgNO3, Fe-EDDHA, and H3BO3. The raw data were statistically analyzed via the graph kernel method to optimize the nonlinear relationship between all parameters. The optimal proliferation medium for T. cilicicus was OM supplemented with a combination of 10 g L-1 charcoal and 1 mg L-1 KIN and the calculated averages of the best regeneration rate, the best shoot number and the best shoot length were 96.89%, 3 and 1.24 respectively on this medium. The determination of genetic stability of in vitro grown plants on the optimum medium compositions obtained by the graph kernel method was carried out with the use of the ISSR-PCR technique. All the ISSR primers produced a total of 192 reproductive band profiles, none of which were polymorphic. Furthermore, the micropropagated plants were successfully rooted and acclimatized to greenhouse conditions. In this study, we present a graph kernel multiple propagation index which considers all the possible parameters needing to be analyzed. Such an index is used for the first time for the determination of the optimum proliferation medium